In order to study the mine water disaster prevention and control theory and the water disaster danger degree of Mayingbao Minefield, the theoretical and test combined method was applied to systematically analyze the hydrological conditions of Mayingbao Minefield and the mine water refilling factors.According to the GI S and AHP coupling theory, a model of floor vulnerability index was established, the water inrush danger of the main mineable seam floors in Mayingbao Minefield was quantitatively evaluated and a subregional drawing for the water inrush vulnerability evaluation of the main mineable seam floors was conducted. The subregional drawi ng could reflect the danger degree of the floor water during the seam mining and could be the basis of the mine water prevention and control during the development an d production of Mayingbao Minefield.