Hebei University of Science & Technology School of Chemical and Pharmaceutical Engineering, Shijiazhuang 050018,China
Shijiazhuang University College of Chemical Engineering
Anesthetic Technology Innovation Center of Hebei Province

建立了阿瑞匹坦结构的研究方法。采用中红外光谱分别开展了阿瑞匹坦结构研究。结果表明，阿瑞匹坦结构的红外吸收模式主要包括：C=O结构伸缩振动模式（ν■）、C=C结构伸缩振动模式（ν■）、CF3结构不对称伸缩振动模式（ν■）、C-F结构伸缩振动模式（ν■）和C-O结构伸缩振动模式（ν■）。阿瑞匹坦结构去卷积MIR光谱的谱图分辨能力要优于相应的一维MIR光谱、二阶导数MIR光谱、四阶导数MIR光谱，并能提供更加丰富的光谱系信息。

A research method for the structure of aprepitant was established. The aprepitant structure were characterized by the mi-infrared (MIR) spectroscopy. The test found that the infrared absorption mode of aprepitant included C=O structure stretching vibration mode (ν■), C=C structural stretching vibration mode (ν■), CF3 structures asymmetric stretching vibration mode (ν■), C-F structure stretching vibration mode (ν■) and C-O structure stretching vibration mode (ν■). It has found that the spectral resolution of the deconvolution MIR spectra of the Arepitan structure is superior to the corresponding one-dimensional MIR spectra, second-order derivative MIR spectra, and fourth-order derivative MIR spectra, and can provide richer spectral information.

王春润1，雷晓静1，周子轩2，常美玲2，于宏伟2，3，张 勇1，常 明2，王丽欣2. 阿瑞匹坦结构中红外光谱研究[J]. 煤炭与化工, 2023, 46(12): 128- 133，150..

Wang Chunrun1, Lei Xiaojing1, Zhou Zixuan2, Chang Meiling2, Yu Hongwei2,3, Zhang Yong1, Chang Ming2, Wang Lixin2. Mid infrared spectral study of arepitan structure. CCI, 2023, 46(12): 128- 133，150..